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This diagram shows the fate of protein (red circles)endocytosed fromthe cell surfaceanddestined forlysosomal destruction.Proteins arefirst found in endocytotic (coated) vesicles that deliver themto earlyendosomes, which arelocated inthe peripheral partofcytoplasm.Because of the sorting capability of the early endosomes, receptors areusually recycled to the plasma membrane, and endocytosed proteins aretransported via multivesicular bodies (MVB)to late endosomes positionednear the Golgi apparatusandthe nucleus.The proteins transported to lateendosomes eventually will be degraded in lysosomes.