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This drawing shows the steps in thephagocytosis of a large particle, suchas a bacterium that has been killed as aresult ofan immune response.The bac-terium is surrounded by antibodies at-tached to the bacterial surface antigens.Fcreceptorsonthe surfaceofthe plasmamembrane ofthe phagocytotic cellsrec-ognize the Fcportion of the antibodies.This interaction triggers rearrangementofactincytoskeleton. It was determined that Treg cell-bound TGF-? was responsible for the induction of this tolerance inducing capability of CD4T cells (Jonuleit 2002)

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